Finding meaning in a meaningless universe is the biological imperative, argues pioneering evolutionary biologist Theodosius Dobzhansky. He contends human consciousness, evolved over eons to seek pattern and purpose, offers a path to discover genuine meaning by exercising our capacities for creativity, ethics, spirituality, and ensuring our choices advance life. While many claim the universe is absent of meaning, Dobzhansky critiques this perspective as incompatible with our nature. He affirms humanity’s calling is to embrace life’s purpose not vainly impose it. Our evolved mind perceives life’s meaning because meaning exists embedded in existence itself. Overall, Dobzhansky makes a stirring case that being human means pursuing meaningful living.